Thursday, March 09, 2017
Protons: The destruction of complex I
It is quite difficult to express how exciting this paper is to a Protons thread True Believer:
The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency.
The paper covers essential everything I've worked at over the past few years about the ratio of NADH to FADH2 as inputs to the electron transport chain. They even give Dr Speijer an honourable mention. I like these people.
Look at the Graphical Abstract, it's pure Protons:
And these are their highlights:
But, as hinted in the highlights, they take it to another level, beyond where I've gotten to in Protons:
The destruction of complex I by eating saturated fat. Or by generating a few ketones.